The original version of DayQuil contains the following ingredients: (1) Dextromethorphan ; Acetaminophen ; Phenylephrine ; All of these ingredients are safe to take with Ibuprofen. However, Acetaminophen is itself a. Feeling under the weather? Wondering if it's safe to mix DayQuil and ibuprofen? Look no further! In this informative video, we'll answer all your questions a.